Verteporfin-PDT treatment induces punctate regions of cytotoxicity concomitant with architectural breakdown of a 3D tumor micronodule. Combined with high content image analysis, this in vitro tumor platform reports a quantitative shift in size distribution towards smaller nodules (Celli et al. J Biomed Opt 2010), suggestive of an increased sensitivity to chemotherapy. Leveraging this 3D system to screen combinations of PDT with traditional chemotherapy reveals a sequence-dependent synergistic enhancement of carboplatin efficacy in ovarian micronodules (Rizvi et al. Cancer Res 2010).

PDT-Induced Disruption of Tumor Micronodules

ASP 2012: 36th Meeting of the American Society for Photobiology


Tayyaba Hasan(thasan@mgh.harvard.edu) David Mitchell(dmitchel@mdanderson.org)
ASP 2012: 36th Meeting of the American Society for Photobiology. Celebrating our 40th Anniversary. 1972-2012

June 23-27, Delta Center Ville, Montreal, Canada
ASP SOCIETY AWARDS ..........Display
Atmospheric Aqueous-Phase Photoreactivity: Correlation Between the Hydroxyl Radical Photoformation and Pesticide Degradation Rate in Atmospherically Relevant Waters ..........Display
Antioxidant Inhibitors Potentiate the Cytotoxicity of Photodynamic Therapy ..........Display

     
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